Editor’s update (May 2026): 37 Actives still makes its Extreme Actives high-performance treatment — the multi-active, single-bottle approach reviewed here. The current 37 Actives range on Amazon carries it.
Most “miracle creams” can’t back up the claim. 37 Actives has a better case than most: it was created by Dr. Macrene Alexiades, a Harvard-trained, Park Avenue dermatologist, and built around dozens of active ingredients in a single jar. Still very much sold in 2026 — now also branded Dr. Macrene Actives — it remains one of the more credible luxury all-in-ones.
What 37 Actives is
37 Actives is a luxury skincare line whose name comes from its original premise: 37 classes of plant-derived active ingredients combined into one high-performance formula. It was created by Dr. Macrene Alexiades, a dermatologist with serious academic credentials, and the brand has since evolved its identity to foreground her name as Dr. Macrene Actives. The current formulas reportedly carry well over fifty lipo-encapsulated actives, the idea being to deliver a comprehensive dose of anti-ageing ingredients in a single step rather than across a shelf of separate products.
The hero all-in-one cream
The flagship is the high-performance anti-aging cream — the product the brand built its reputation on. The pitch is ambitious: a single cream that aims to do the work of a multi-step routine, addressing firmness, fine lines, tone and hydration at once, with the brand even framing it as an alternative to certain cosmetic procedures. Whether or not it lives up to that for every user, the logic appeals to a specific buyer: someone who wants maximum potency with minimum steps, and is willing to pay for a heavily-formulated, encapsulated-actives approach rather than buying five separate serums.
The science and credentials
What separates 37 Actives from the average department-store “anti-ageing” cream is the person behind it. Dr. Macrene Alexiades is a practising dermatologist with strong academic credentials, and the brand leans on lipo-encapsulation — a delivery method designed to carry actives more effectively and release them over time. That dermatologist authorship and ingredient-delivery focus is the brand’s central claim to legitimacy, and it’s why it sits on the shelves of luxury retailers rather than the drugstore.
Who it’s really for
This is for the luxury skincare buyer who wants a potent, do-it-all anti-ageing cream and would rather invest in one heavily-formulated product than assemble a complicated routine. It suits mature skin focused on firmness, lines and overall rejuvenation, and people who specifically value a dermatologist-formulated pedigree. It is unambiguously a splurge, so it isn’t for budget-focused shoppers — but for the right person, the all-in-one convenience is part of the value.
How to use it
As an all-in-one, it’s designed to simplify rather than complicate: cleanse, then apply the cream as your main treatment-and-moisturiser step, morning and/or night per the brand’s guidance. Pair it with daily sunscreen in the morning, since sun protection is essential to any anti-ageing routine. Because it’s a rich, active-dense formula, introduce it steadily if your skin isn’t used to potent actives, and give it consistent use over weeks to judge results fairly.
Is it worth it, and where to buy
For those who want a credible, dermatologist-formulated luxury all-in-one and value simplicity at the high end, 37 Actives makes a stronger case than most creams in its price bracket. You can buy it direct from macreneactives.com, and it’s stocked at luxury retailers including Neiman Marcus and specialty beauty boutiques. It’s a considered splurge rather than an impulse buy — but a coherent one.
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Frequently asked questions
Is 37 Actives still sold in 2026?
Yes. The brand is still sold in 2026, now also branded Dr. Macrene Actives, available at macreneactives.com and luxury retailers such as Neiman Marcus and specialty beauty boutiques.
Who created 37 Actives?
Dr. Macrene Alexiades, a Harvard-trained, Park Avenue dermatologist. Her credentials and the brand’s encapsulated-actives approach are central to its positioning, which is why it has been rebranded to foreground her name.
What makes the cream different?
It’s an all-in-one: dozens of lipo-encapsulated active ingredients in a single formula, designed to address firmness, lines, tone and hydration at once rather than across multiple products.
Is 37 Actives worth the price?
If you want a potent, dermatologist-formulated luxury cream and prefer one comprehensive product to a multi-step routine, it makes a strong case. It’s firmly a splurge, so budget-focused shoppers will find it expensive.