Editor’s update (May 2026): Perricone MD has reformulated and renamed its flagship treatment many times since this review, but the single-cream, anti-inflammatory approach still defines the brand. The current Perricone MD treatment moisturisers on Amazon are the closest pick.
The treatment cream from Perricone MD built around a single proprietary anti-inflammatory complex. Formula 1 is the brand’s flagship — a single product designed to address multiple aging concerns through cellular-level intervention.
What’s in it
Perricone‘s signature anti-inflammatory complex, supported by peptides, antioxidants, and a hydration system designed to layer with everything else in your routine.
How it wears
A small amount, pressed into clean skin twice a day. Texture is rich but absorbs cleanly. Skin tolerates it without irritation, and pairs well under SPF and makeup.
The single-product treatment worth knowing about if your routine has expanded too far.
Shop the post
👉 Shop Perricone MD moisturisers on Amazon
As an Amazon Associate I earn from qualifying purchases. Read full disclosure.